Probenecid at the Nexus of Multidrug Resistance and Neuro...

2025-10-18

This thought-leadership article provides an in-depth exploration of Probenecid’s multidimensional role as an inhibitor of organic anion transporters, multidrug resistance-associated proteins (MRPs), and pannexin-1 channels. With direct reference to recent immunometabolic discoveries and translational oncology-neuroscience intersections, it offers mechanistic clarity, validated workflows, and a forward-looking roadmap for researchers seeking to overcome multidrug resistance and neuroinflammation. The discussion is enriched by critical findings from high-impact literature and internal knowledge assets, delivering actionable insights that go beyond conventional product resources.